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In Vivo Imaging and Tracking of Bio-Conjugate Nanoparticles using High Field (7T) Magnetic Resonance Imaging
Keywords: Biomolecular sensor, magnetic nanoparticles, hyperthermia
The goal of this research is to develop a “Biomolecular Sensor” with magnetic nanoparticles implanted in it to detect and destroy cancerous cells by thermal ablation. The “Biomolecular sensor” consists of superparamagnetic iron oxide nanoparticles with externally attached antibodies. The antibodies will function as targeting agents to a specific tumor site. Superparamagnetic nanoparticles will be subjected to an AC magnetic field to generate heat, which is used to destroy cancerous cells. The aim of this research is to develop such a nanoparticle based biosensor and optimize the amount of AC field magnitude, frequency and the relative time of exposure required for temperature elevation to destroy cancerous cells. This procedure of destroying cancerous cells by elevating temperature inside the tumor tissue is referred as “Hyperthermia”. This process represents a minimal invasive alternative for elimination of cancer cells at appropriate sites and is less harmful and preferred to other therapies such as laser ablation, chemotherapy, radiotherapy, etc. This process prevents the unnecessary heating of healthy tissues since only the injected magnetic particles in the tumor region absorb the magnetic field. In this study iron oxide nanoparticles-magnetite and maghemite synthesized via co-precipitation method will be exposed to AC magnetic field to achieve hyperthermia. Magnetite and maghemite are ideal candidates for hyperthermia cancer treatment as they are highly biocompatible, exhibit low levels of toxicity and show high saturation magnetic moment.
Asha Seshadri, Student
Temple University
Philadelphia, PA

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