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Computer Modeling of Induced Hyperthermia Using Superparamagnetic Iron Oxide Nanoparticles and their Application
Keywords: superparamagnetic, hyperthermia, Ion Oxide nanoparticles
The focus of this paper revolves around the mathematical realization of RF-induced hyperthermia models for the effective ablation of brain tumors. This process requires a precise view of the magnetic field interactions with the SuperParamagnetic Iron Oxide (SPIO) nanoparticles, which are suspended in a gelatin that can emulate several properties of brain tissue. For empirical data gathering, the physical system used in the process consists of a Hot Shot RF Unit as developed by Ameritherm Inc. This approach produces an AC magnetic field through induction. The magnetic fluid is subjected to an alternating field whereby the magnetic moments of these single domain particles are constantly oscillating and resulting in frictional heat losses. With the development of a targeting ligant for efficient biodistribution, these particles will adhere to the neoplasm and kill the tumor through controlled AC exposure. A model has been developed that can estimate the effects of changing certain parameters, such as coil diameter, time of exposure, and field strength in terms of the thermodynamics for heat and mass diffusion. These particles also have the potential to be used as MR contrast agents for rapid tumor detection due to the targeted delivery system and high relaxivities. Antibodies or other biological entities can be attached to the cross linked dextran coating for specificity studies. Due to the low toxicity and relatively long blood half life of cross linked iron oxides, they are the ideal candidate for advanced cancer therapies and diagnostic imaging techniques.
Chris Conklin, Student
Temple University
Philadelphia, PA

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