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LTCC Flow-Through Amperometric Detector for Glucose Determination
Keywords: sensor, microdialysis, glucose
In this paper, a flow-through amperometric detector made with use of LTCC (Low Temperature Co-fired Ceramics) technology will be presented. The microsystem consists of a microreactor, three thick-film electrodes and a semi-permeable dialysis tube. Volume of the reaction chamber was around 5 ul. The principle of LTCC flow-through amperometric sensor operation is based on a semi-permeable capillary, which is build into the microreactor. A sample containing analyte is transported along the capillary. The analyte (glucose) diffuses from the sample through a semi-permeable dialysis tube to the microreactor. The microreactor is filled with aqueous solution containing the free enzyme (glucose oxidase type II, GOx). In presences of the GOx, the glucose is oxidized.. One of the reaction product is a hydrogen peroxide. The hydrogen peroxide generated in reaction is electrochemically oxidized at an anode. The current resulting from the reaction is a measurand as it is proportional to the glucose concentration in the sample. The shape of the LTCC flow-through amperometric detector is optimized with use of the CFD (Computational Fluid Dynamics) analyze. The fluidic channels and reaction chamber were patterned in DP951 LTCC tapes by the Nd-YAG laser. All electrodes has been located at the bottom of the reaction cell and they are made by a standard screen-printing method. Working electrode (WE) and counter electrode (CE) are deposited with use of Pt ink, whereas a reference electrode (RE) is deposited with use of Ag ink. The silver/silver chloride RE electrode is made by electrochemical chloriding of silver pad in 0.1 M potassium chloride. The LTCC flow-through amperometric sensor has shown a linear response in a wide range of glucose concentration 0-10 mM. Moreover, the output signal of the LTCC sensor was about ten times higher in comparison with the output signal measured for a similar sensor made in silicon.
Karol Malecha,
Wroclaw University of Technology
Wroclaw, Dolnoslaskie 50-370 ,
Poland


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