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|Biocompatible low temperature co-fired ceramic for biosensors|
|Keywords: LTCC, biocompatible, biosensor|
|Low temperature co-fired ceramic (LTCC) electronic packaging materials are applied for their ease of fabrication, three dimensional features and integration of multifunctional component, such as optical and electrical functions. For these reasons LTCC is attractive for biomedical microfluidics and Lab-on-a-Chip systems. However, commercial LTCC system, optimized for microelectrics applications, have unknown cytocompatibility, and not designed for biomedical applications. In the current work, LTCC has been developed starting with materials of known composition and biocompatibility. The LTCC fabricated from a lime silicate glass and pure alumina exhibits low sintering temperature (<1000OC) and high density. Alumina reacts with the glass and forms anorthite type crystalline phase CaAl2Si2O8 at temperature 900OC. TC8101 gold electrode has also been co-fired with the LTCC, and no delamination, cracks and camber have been observed. In-vitro biocompatibility of LTCC has been evaluated using human umbilical vein endothelial cells (HUVEC). The HUVECs attached and spread on the surface of the LTCC substrates, and also in the leachate obtained by soaking LTCC in cell media for five days. The cell density and percentage of live cells on LTCC surface were comparative with those of control. Those results indicate developed LTCC are biocompatible for biomedical applications.|
|Jin Luo and Richard Eitel, Graduate
Department of Chemical and Materials Engineering, University of Kentucky