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Improved Trans-endothelial Electrical Resistance Sensing using Microfluidic Low-Temperature Co-fired Ceramics
Keywords: lab on chip, biosensing, microfluidics
The expansion of Trans-Endothelial Electrical Resistance measurements into microfluidic systems using Low-Temperature Co-fired Ceramic technology has many beneficial applications due to their ability to combine complex three dimensional structures with fluidic and electronic functions. Under natural environment, endothelial cells are augmented to align in the direction of flow. Low-Temperature Co-fired Ceramic technology has the capability for Trans-Endothelial Electrical Resistance measurements to be obtained under physiological conditions. The goal of the current study was to develop a simple Low-Temperature Co-fired Ceramic Trans-Endothelial Electrical Resistance based device. This study compares the detection limits of commercially available products and our Low-Temperature Co-fired Ceramic system. Findings show Trans-Endothelial Electrical Resistance measurements generated from the devices as a function of cell growth. Results also indicate that Low-Temperature Co-fired Ceramics are biocompatible with human umbilical vein endothelial cells.
Richard E Eitel, Assistant Professor
University of Kentucky
Lexington, KY

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