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An LTCC based microfluidic calorimeter and detection scheme for rapid biomarker detection
Keywords: Biosensor, Microfluidic, Calorimeter
Protein based biomarkers are increasingly being considered for their diagnostic potential in a number of critical and hard to diagnosis medical conditions. However, current biomarker detection strategies are time consuming and require sophisticated and expensive analytical capabilities. In the current work a self-contained and low cost LTCC ceramic microfluidic biosensor has been developed for conducting enzyme-linked immunosorbent assays (ELISA) using a novel polymerization amplified thermal detection (PATD) scheme. Prototype testing has yielded several results that support the viability of this device. It was seen that LTCC is an effective and durable substrate for the temperature sensor. Noise testing with our prototype revealed that our temperature sensors can detect changes as small as 0.01 K. Additional temperature testing showed that the thermistor behavior matches the expected thermistor beta equation. Finally, it was shown that the induction time of PATD is inversely proportional to glucose oxidase (GOx) initiator concentration. These preliminary results provide a foundation for future work developing the sensor into a protein detection device with cancer prognosis applications.
Ben Brummel,
University of South Carolina
Columbia, SC

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